Cannabidiol (CBD) is a substance derived from the cannabis plant. A increasing amount of research suggests that cannabidiol (CBD) may be beneficial for persons who suffer with fibromyalgia.
Fibromyalgia is a persistent pain syndrome that affects the muscles and joints. Research suggests that cannabidiol (CBD) may be useful in the treatment of pain and inflammation, and scientists are investigating its impact on the symptoms of fibromyalgia.
In one 2020 review, for example, the authors concluded that, while current evidence is still limited, emerging data suggests that cannabis may have a beneficial effect on fibromyalgia sufferers.
Furthermore, although CBD appears to have potential as a treatment for this condition, research has not yet demonstrated that it is both safe and effective, and the Food and Drug Administration (FDA) has not approved CBD for the treatment of fibromyalgia or other forms of pain. Trusted Source
CBD, on the other hand, continues to be a popular option. This essay will investigate the reasons why CBD may be able to alleviate the discomfort associated with fibromyalgia. It will also look at some of its most beneficial applications as well as some potential adverse effects.
Is Cannabidiol (CBD) legal? CBD products derived from hemp that contain less than 0.3 percent THC are allowed under federal law, but they are still banned under several state regulations. CBD-derived products manufactured from cannabis, on the other hand, are prohibited under federal law but allowed under some state regulations. When travelling, especially in foreign countries, always sure to check local legislation. It’s also important to remember that the Food and Drug Administration (FDA) has not approved nonprescription CBD products, which may be labelled incorrectly.
Is CBD the same as cannabis?
CBD is not the same thing as cannabis, to put it simply.
CBD is one of more than 100 cannabinoids found in the cannabis plant, and it is thought to have medicinal properties. An other component included in cannabis, known as tetrahydrocannabinol (THC), is responsible for the sensation of being high.
The majority of CBD oil available on the market is derived from a form of cannabis known as hemp, which is required to contain less than 0.3 percent THC by law to be sold.
Concentrated CBD oil has the potential to provide higher benefits while posing fewer hazards than medical cannabis.
CBD and fibromyalgia
Researchers are still unable to determine why the molecule appears to alleviate some fibromyalgia symptoms, or why it works for some patients but not others, but they are actively investigating several hypotheses.
It is believed that CBD’s pain-relieving properties are due to its effects on the central nervous system. It has the potential to disrupt the neural pathways that transmit pain signals between the brain and the rest of the body.
CBD and other cannabinoids bind to specific receptors in the brain of the individual who consumes them. One of these receptors, known as a CB2 receptor, is involved in the management of pain and inflammation, among other things.
When CBD enters the body, it may attach to CB2 receptors or it may cause the body to produce natural cannabinoids (endocannabinoids) that attach to these receptors. When CBD enters the body, it may cause the body to produce natural cannabinoids (endocannabinoids) that attach to these receptors. Reduced pain and inflammation are possible outcomes of this procedure.
According to a study published in 2016, a deficiency in endocannabinoids may be at the basis of chronic pain disorders such as migraine and fibromyalgia, among others.
The use of CBD may be able to remedy this deficiency, which may explain the efficacy of the substance in the treatment of chronic pain.
However, research is still in its early stages, and more studies are required before researchers can have a complete understanding of this process.
Is CBD effective?
A high-quality research study of this therapy procedure is currently being conducted by scientists. In the past, research has concentrated on medical cannabis as a whole rather than on CBD in specific. New research is uncovering the health benefits associated with this chemical.
According to the National Centers for Complementary and Integrative Health, some evidence suggests that cannabis or CBD may have minor benefits in the treatment of chronic pain, however more research is needed.
For example, according to a 2020 review, CBD may be beneficial in certain circumstances for the relief of chronic pain, the improvement of sleep, and the reduction of inflammation.
Learn more about using CBD for chronic pain here.
Anecdotal evidence also suggests that taking CBD oil may be beneficial in alleviating the symptoms of fibromyalgia in some individuals.
People suffering from chronic pain conditions such as fibromyalgia, migraine, and irritable bowel syndrome may benefit from CBD, according to research. CBD has been shown to relieve pain, improve sleep, and reduce refractory pain in a variety of studies.
Most medicinal cannabis patients are likely to consume some CBD, while the exact amount is not known for certain. If CBD is used alone or in conjunction with medical cannabis, there is some controversy as to which is more effective.
Combining CBD with other compounds found in the plant may enhance the favourable effects of CBD while also bringing about other benefits. For example, according to a 2006 study, CBD is most effective when used in conjunction with THC.
Researchers will need more evidence before they can determine the true usefulness and safety of CBD in the treatment of pain and chronic health issues.
What do the studies say?
According to the findings of a 2020 study, growing evidence suggests that cannabis may have a beneficial effect on fibromyalgia. The researchers, on the other hand, point out that the available evidence is still restricted.
A randomised trial conducted in 2019 examines the effects of Bediol, a medication that combines both CBD and THC, on persons who suffer from fibromyalgia. People who took Bediol reported a 30 percent reduction in pain scores, according to the study, which was conducted in comparison to those who took a placebo.
Other findings from this study, on the other hand, were ambiguous, and it is unclear whether the effects were caused by THC or by CBD.
According to the findings of a 2017 study, CBD may be able to reduce the responsiveness of cells surrounding neurones in persons suffering from chronic pain, such as those suffering from fibromyalgia. On the other hand, it also demonstrates the need for additional research in this area.
Currently available studies regarding cannabis use for chronic pain, while not specifically for pain associated with fibromyalgia, was examined in a 2015 review. Seven out of the eleven research included in the review suggest that CBD is an effective pain reliever.
The findings of 28 randomised, clinically controlled studies of medical cannabis as a pain reliever were examined in another review published in 2015, which is available online. A large number of the trials were focused on the discomfort associated with multiple sclerosis. According to the findings of the review, high-quality evidence supports the use of medical cannabis to alleviate chronic pain in some circumstances.
Does synthetic cannabis work?
One review from 2016 examines the impact of a synthetic cannabinoid known as Nabilone on the symptoms of fibromyalgia. According to the researchers, it was poorly accepted by the subjects, and it provided no statistically significant benefits when compared to a placebo.
Synthetic cannabinoids, on the other hand, according to a review published in 2020, “are one of the most promising families of medications in the field of pain medicine.”
Because there has only been minimal research on the effects of synthetic cannabis, researchers are presently investigating its effectiveness.
Why has finding evidence been difficult?
The benefits of CBD oil have only been demonstrated in small human trials, owing to the fact that cannabis usage and study are still prohibited in most countries.
As cannabis becomes more widely legalised in many jurisdictions, scientific investigation is gathering steam and beginning to yield some encouraging results.
Many researches of CBD have limitations, including the following:
- very small participant numbers
- conflicting results
- a lack of control groups or placebos
- a lack of objective measures, relying instead on self-report measures
Other difficulties that researchers face include sourcing high quality CBD or medical cannabis (due to a lack of regulation) and controlling the dosage and potency of CBD products.
Despite the fact that a small number of studies have suggested that CBD is useful for fibromyalgia, the evidence remains mixed and unclear.
How to Make Use of CBD Oil
There are a variety of websites that provide directions for utilising CBD oil, but there is little expert insight into how to use it or what dosage to use it at. Some people use the oil topically, while others use it orally.
In order to get the best results, patients should consult with a doctor who is familiar with CBD and fibromyalgia before making any decisions on dosing.
Like any medication, it is best to begin with a low dose and monitor the body’s response carefully.
More information about CBD dosing can be found here.
Because CBD products are not regulated by the FDA in the same manner that pharmaceuticals are, firms may mislabel or misrepresent their goods on the market.
Side effects
CBD is typically well tolerated by most people, however some have reported negative side effects. Some of the most common adverse effects are as follows:
- dizziness
- nausea
- dry mouth
- drowsiness
Before consuming CBD, people should consult with their physician. CBD may interact with certain over-the-counter medications, dietary supplements, and prescription medications, particularly those that warn against consuming grapefruit. CBD may also interact with certain prescription medications.
In addition, there are some worries that CBD may interfere with the liver’s ability to break down toxins by interfering with the activity of an enzyme known as the cytochrome P450 complex.
Legality
Despite the fact that hemp and hemp-derived products containing less than 0.3 percent THC are lawful under the Farm Bill, there is still considerable ambiguity about the provisions of the legislation.
A lot of research is still being done, and the legal position of CBD and other cannabinoids differs from one state to another.
If a person in the United States is considering using CBD, they may find out more about the legislation in their area by visiting this page.
Conclusion
Fibromyalgia is a persistent pain condition that affects the entire body. Some people find that CBD can help them manage their symptoms, despite the fact that it will not cure them. Research into this area shows promise, as well.
Sources
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204604/
- https://pubmed.ncbi.nlm.nih.gov/33004171/
- https://dialnet.unirioja.es/servlet/articulo?codigo=5277220
- https://pdfs.semanticscholar.org/4d12/db2a249cc22cb8e78f31586ff0036b8bce9d.pdf
- http://www.drugpolicy.org/blog/what-cbd-marijuana-and-whats-big-deal-about-it
- https://www.nccih.nih.gov/health/cannabis-marijuana-and-cannabinoids-what-you-need-to-know
- https://www.ncbi.nlm.nih.gov/books/NBK425757/
- https://www.fda.gov/NewsEvents/PublicHealthFocus/ucm421168.htm
- https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm611046.htm
- https://www.fda.gov/news-events/press-announcements/statement-fda-commissioner-scott-gottlieb-md-signing-agriculture-improvement-act-and-agencys
- https://www.fda.gov/consumers/consumer-updates/grapefruit-juice-and-some-drugs-dont-mix
- https://www.medicalnewstoday.com/articles/321501
- https://jamanetwork.com/journals/jama/article-abstract/2338266?redirect=true
- https://www.brookings.edu/blog/fixgov/2018/12/14/the-farm-bill-hemp-and-cbd-explainer/
- https://www.liebertpub.com/doi/10.1089/can.2016.0034
- https://www.ncbi.nlm.nih.gov/books/NBK556048/
- https://link.springer.com/article/10.1007/s11481-015-9600-6
- https://www.tandfonline.com/doi/abs/10.1080/14728222.2017.1353603
- http://www.medical-hypotheses.com/article/S0306-9877(05)00431-7/fulltext
- https://www.liebertpub.com/doi/full/10.1089/can.2016.0009
- https://www.karger.com/Article/Abstract/443890
- http://www.ncsl.org/research/health/state-medical-marijuana-laws.aspx
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023162/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430597/
- http://cochranelibrary-wiley.com/doi/10.1002/14651858.CD011694.pub2/full
